2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126963
    Mal-PEG6-acid 518044-42-3 98.96%
    Mal-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG6-acid
  • HY-140803
    Azide-PEG12-alcohol 1821464-55-4 99.81%
    Azide-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG12-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG12-alcohol
  • HY-133277
    m-PEG2-Br 54149-17-6 98.50%
    m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG2-Br
  • HY-22391
    tert-Butyl (7-aminoheptyl)carbamate 99733-18-3
    tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660).
    tert-Butyl (7-aminoheptyl)carbamate
  • HY-141016
    (S,R,S)-AHPC-PEG2-acid 2172820-09-4 98.88%
    (S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    (S,R,S)-AHPC-PEG2-acid
  • HY-124323
    m-PEG4-NHS ester 622405-78-1
    m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-NHS ester
  • HY-140135
    PC-Biotin-PEG4-NHS carbonate 2055198-03-1
    PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PC-Biotin-PEG4-NHS carbonate
  • HY-W007529
    Boc-6-aminohexanoic acid 6404-29-1 ≥98.0%
    Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-6-aminohexanoic acid
  • HY-140697
    m-PEG-OH (MW5000) 9004-74-4 ≥98.0%
    m-PEG-OH (MW5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-OH (MW5000)
  • HY-W004447
    Pentaethylene glycol di(p-toluenesulfonate) 41024-91-3 98.34%
    Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol di(p-toluenesulfonate)
  • HY-W006635
    Bpin-Cyclohexene-COOEt 1049004-32-1
    Bpin-Cyclohexene-COOEt (Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate) is a PROTAC linker belonging to the PEG class. Bpin-Cyclohexene-COOEt can be used to synthesize PROTAC molecules.
    Bpin-Cyclohexene-COOEt
  • HY-W007322
    Boc-NH-PEG1-OH 26690-80-2 99.51%
    Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-OH
  • HY-140832
    m-PEG24-azide 2563873-82-3
    m-PEG24-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG24-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG24-azide
  • HY-141373
    Bromo-PEG3-bromide 31255-26-2 98.10%
    Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG3-bromide
  • HY-140617
    DNP-PEG3-azide 951671-87-7 99.40%
    DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DNP-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DNP-PEG3-azide
  • HY-141236
    HO-PEG20-OH 351342-08-0 98.22%
    HO-PEG20-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG20-OH
  • HY-140256
    NH-bis(PEG2-C2-Boc) 1964503-36-3 ≥98.0%
    NH-bis(PEG2-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(PEG2-C2-Boc)
  • HY-133388
    Boc-NH-C12-NH2 109792-60-1
    Boc-NH-C12-NH2 is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C12-NH2
  • HY-140909
    Biotin-PEG11-Mal 1646619-56-8 98.12%
    Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG11-Mal
  • HY-W071584
    N-Boc-PEG6-alcohol 331242-61-6
    N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG6-alcohol
PROTAC Linkers Isoform Comparison

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